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Wir freuen uns sehr im Jahr 2019 die 12. Europäische Konferenz für Tourette Syndrom und Tic-Störungen hier bei uns in Hannover willkommen zu heißen. D...

12. Europäische Konferenz für Tourette Syndrom und Tic-Störungen (ESSTS) in Hannover vom 15.-17. Mai 2019

April 3, 2019

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Gilles de la Tourette syndrome is associated with hypermethylation of the dopamine D2 receptor gene

Gilles de la Tourette syndrome is associated with hypermethylation of the dopamine D2 receptor gene

Several lines of evidence support a “dopaminergic hypothesis” in the pathophysiology of Gilles de la Tourette syndrome (TS). The aim of this study was to investigate for the first time epigenetic changes in DNA methylation in different dopamine genes in adult patients with TS. We included 51 well characterized adult patients with TS (41 males, 10 females, mean age = 35 ± 12.6 years, range, 18–71 years) and compared results with data from a group of 51 sex- and age-matched healthy controls. Bisulfite sequencing was used to measure peripheral DNA methylation of the dopamine transporter (DAT), the dopamine D2 receptor (DRD2), and the catechol-O-methyltransferase (COMT) genes. Compared to healthy controls, patients with TS showed significantly elevated methylation level of the DRD2 gene that positively correlated with tic severity.

 

https://dx.doi.org/10.1016/j.jpsychires.2016.11.004